Biochem/physiol Actions

Cell permeable: no

Reversible: no

Target K_i: 24 nM against GSK-3

Primary TargetGSK-3

Product does not compete with ATP.

General description

A potent and ATP-competitive inhibitor of GSK-3 (K_i = 24 nM).

An aminopyrazole compound that acts as a potent and ATP-binding site inhibitor of GSK-3 with a K_i of 24 nM.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Pierce, A.C., et al. 2005. J. Med. Chem.48, 1278.

Packaging

1, 5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)